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Journal Article 4

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MYC 2

HDAC inhibitor 1

MAX 1

MLX 1

NOTCH1 1

T-cell acute lymphoblastic leukemia 1

c-Myc 1

cancer 1

chidamide 1

different 1

molecular mechanism 1

network 1

synthetic lethality 1

transcriptase-polymerase 1

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ubiquitination 1

understood 1

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Targeting “undruggable” c-Myc protein by synthetic lethality

Chen Wang, Hui Fang, Jiawei Zhang, Ying Gu

Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 541-550 doi: 10.1007/s11684-020-0780-y

Abstract: This method provides a new avenue for targeting “undruggable” proteins, such as c-Myc.Here, we revisit current methods used to target c-Myc and discuss the important functional nodes relatedto c-Myc in non-oncogene addicted network, whose inhibition may cause a catastrophe for tumor cell destiny

Keywords： synthetic lethality undruggable transcription factor c-Myc

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3, Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: In particular, chidamide inhibits the NOTCH1-MYC signaling axis by down-regulating the level of the intracellularform of NOTCH1 (NICD1) as well as MYC, partly through their ubiquitination and degradation by the proteasome

Keywords： T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

Patrick A. Carroll, Brian W. Freie, Haritha Mathsyaraja, Robert N. Eisenman

Frontiers of Medicine 2018, Volume 12, Issue 4, Pages 412-425 doi: 10.1007/s11684-018-0650-z

Abstract: In this review we focus on the MYC network (also known as the MAX-MLX Network), a highly conserved super-familyImportantly the MYC network has been shown to be deeply involved in a broad spectrum of human and otherMoreover, oncogenic activation of MYC and/or loss of a MYC antagonist, results in an imbalance in the

Keywords： network transcription cancer MYC MAX MLX

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Abnormal expression of c-Myc in human bronchial epithelial cells malignantly transformed by anti-BPDE

FU Juan, JIANG Yiguo, CHEN Xuemin

Frontiers of Medicine 2008, Volume 2, Issue 4, Pages 380-385 doi: 10.1007/s11684-008-0073-3

Abstract: The levels of mRNA and protein of c-Myc were examined in the 16HBE-T and vehicle-treated control cellsLikewise, the expression of c-Myc protein was significantly enhanced as compared with those of the controlMoreover, the localization of c-Myc protein shows mainly nuclear staining in 16HBE-T.In conclusion, the abnormal expression of c-Myc was present in anti-BPDE malignantly transformed 16HBE

Keywords： transcriptase-polymerase vehicle-treated understood molecular mechanism different